Research Grants 2020-2021

The RYR-1 Foundation is very excited to announce the recipients of the Foundation’s most recent round of research grants. These grants represent a commitment of over $450,000 of research funding. The awardees represent leaders from around the world in the field of RYR-1-related research.

János Almássy, PhD, University of Debrecen (Hungary): “Functional and pharmacological characterization of the T4709M mutant ryanodine receptor at single-channel level”

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Razvan, Cornea, PhD, University of Minnesota, Minneapolis: “High-Throughput Screens to Discover Novel Modulators of Dysfunctional RyR1 Channels for Therapeutic Development”

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Bradley Launikonis, PhD, The University of Queensland (Australia): “Assessment of the ability of small molecule RyR modulators to correct the Ca2+ fluxes in skeletal muscle fibers with RyR myopathy”

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Vincenzo Sorrentino, MD, University of Siena (Italy): ”Endoplasmic Reticulum stress in skeletal muscles of patients with Central Core Disease and other RYR1-related myopathies: a potential mechanism of disease and a druggable target”

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Joshua Todd, PhD, CCRP, National Institute of Nursing Research: “Mitoquinol mesylate and n-3 polyunsaturated fatty acids: a novel therapeutic approach for RYR1-related myopathy”

Research Grants 2017-2018

The RYR-1 Foundation is very excited to announce the recipients of the Foundation’s 2017-2018 round of research grants. These grants represent a commitment of over $500,000 of research funding. The awardees represent leaders in the fields of CRISPR/gene editing, muscle functioning, and RYR-1 protein structure. Please click on the recipients below to read the abstract of their research.

Angela Dulhunty, MD, PhD, Australian National University (Australia): “Developing Animal Models with an RYR-1 Mutation and Clinical Phenotype for the Purpose of Evaluating Cell and Molecular Mechanisms of RYR-1 Disease”

Alexander Kushnir, MD, PhD, Columbia University: “RyR1 Myopathy Database”

William R. Lagor, PhD, Baylor College of Medicine: “Targeted Removal of Pathogenic RYR1 Alleles”

Filip Van Petegem, PhD, University of British Columbia (Canada): “Structural Investigation of Disease-Associated Mutations in the Ryanodine Receptor Pore and EF Hand Region”

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inGenious Targeting Laboratory: Development of RYR-1 Mouse Models