Research Grants 2021-2022

The RYR-1 Foundation is very excited to announce the recipients of the Foundation’s most recent round of research grants. These grants represent a commitment of over $270,000 of research funding. The awardees seek to apply cutting-edge, innovative therapeutic techniques to RYR-1-related diseases.

Jocelyn Laporte, PhD, Institute of Genetics and Molecular and Cellular Biology (France): “Therapeutic proof-of-concepts for RYR1-related myopathy”

 

Jacques Tremblay, PhD, Laval University (Canada): “PRIME editing correction of the T4709M mutation responsible for some cases of Ryanodine receptor type 1 (RYR1) related myopathies (RYR1 RM)” 


Susan Treves, PhD, and Francesco Zorzato, MD, PhD, University of Basel (Switzerland): “Treatment of an animal model carrying recessive RYR1 mutations with HDAC/DNA methyltransferase inhibitors” 

Research Grants 2020-2021

The RYR-1 Foundation is very excited to announce the recipients of the Foundation’s most recent round of research grants. These grants represent a commitment of over $450,000 of research funding. The awardees represent leaders from around the world in the field of RYR-1-related research.

János Almássy, PhD, University of Debrecen (Hungary): “Functional and pharmacological characterization of the T4709M mutant ryanodine receptor at single-channel level”

Razvan, Cornea, PhD, University of Minnesota, Minneapolis: “High-Throughput Screens to Discover Novel Modulators of Dysfunctional RyR1 Channels for Therapeutic Development”

Bradley Launikonis, PhD, The University of Queensland (Australia): “Assessment of the ability of small molecule RyR modulators to correct the Ca2+ fluxes in skeletal muscle fibers with RyR myopathy”

Vincenzo Sorrentino, MD, University of Siena (Italy): ”Endoplasmic Reticulum stress in skeletal muscles of patients with Central Core Disease and other RYR1-related myopathies: a potential mechanism of disease and a druggable target”

Joshua Todd, PhD, CCRP, National Institute of Nursing Research: “Mitoquinol mesylate and n-3 polyunsaturated fatty acids: a novel therapeutic approach for RYR1-related myopathy”

Research Grants 2017-2018

The RYR-1 Foundation is very excited to announce the recipients of the Foundation’s 2017-2018 round of research grants. These grants represent a commitment of over $500,000 of research funding. The awardees represent leaders in the fields of CRISPR/gene editing, muscle functioning, and RYR-1 protein structure. Please click on the recipients below to read the abstract of their research.

Research Grants 2015-2016

Alan Beggs, PhD, Harvard Medical School: "Drug Discovery for RYR-1 Myopathies Using Zebrafish Models"

Robert T. Dirksen, PhD, University of Rochester & James Dowling, MD, PhD, Hospital for Sick Children (Canada): "Drug Discovery and Validation for RYR-1-Related Myopathies"

James Dowling, MD, PhD, Hospital for Sick Children (Canada): "Cas9-Mediated Point Mutagenesis of RYR-1"

Andrew R. Marks, MD, Columbia University & Katy Meilleur, PhD, CRNP, National Institute of Nursing Research (previously): "Rycal Treatment in RYR-1-Related Myopathy Muscle Biopsies"